Abstract Search

ea0077p107 | Reproductive Endocrinology | SFEBES2021

A randomised controlled trial on the effect of very-low-calorie diet (VLCD) vs. an energy deficit diet, in women with the polycystic ovary syndrome (PCOS) – remission PCOS

Deshmukh Harshal , Papageorgiou Maria , Wells Liz , Akbar Shahzad , Strudwick Tom , Reid Marie , Sathyapalan Thozhukat

PCOS is the most common endocrine disorder affecting the women of reproductive age group and weight loss is the mainstay of management of PCOS. We performed an open-label randomised controlled trial to compare the effects of a conventional energy deficit approach (-600 kcal/day of the total energy requirements) vs. a very low-calorie diet (VLCD: 800 kcal/day) on free androgen index (FAI), body weight, and metabolic markers in women with PCOS. Forty-one eligible patients were r...

0 shares

ea0065op3.4 | Metabolism and Obesity | SFEBES2019

Mice with a gain-of function Gα₁₁ mutation have autosomal dominant hypocalcaemia, but not impaired glucose metabolism

Gluck Anna , Lines Kate , Gorvin Caroline , Babinsky Valerie , Piret Sian , Sarbu Stefan , Stewart Michelle , Bentley Liz , Wells Sara , Cox Roger , Ecker Rupert , Ellinger Isabella , Hannan Fadil , Thakker Rajesh

The calcium-sensing-receptor (CaSR) is a G-protein-coupled receptor that plays a fundamental role in extracellular calcium homeostasis, but is also implicated in non-calcitropic disorders including colon cancer and asthma. In addition, CaSR is highly expressed in pancreatic islets where it has a role in insulin secretion. Patients with gain-of-function CaSR mutations, and mice (referred to as Nuf) with a gain-of-function CaSR mutation (Leu723Gln), develop autosomal dominant hy...

0 shares

Endocrine Abstracts

A randomised controlled trial on the effect of very-low-calorie diet (VLCD) vs. an energy deficit diet, in women with the polycystic ovary syndrome (PCOS) – remission PCOS

Mice with a gain-of function Gα₁₁ mutation have autosomal dominant hypocalcaemia, but not impaired glucose metabolism

BiosciAbstracts

Endocrine Abstracts

A randomised controlled trial on the effect of very-low-calorie diet (VLCD) vs. an energy deficit diet, in women with the polycystic ovary syndrome (PCOS) – remission PCOS

Mice with a gain-of function Gα11 mutation have autosomal dominant hypocalcaemia, but not impaired glucose metabolism

BiosciAbstracts

Mice with a gain-of function Gα₁₁ mutation have autosomal dominant hypocalcaemia, but not impaired glucose metabolism